Services

Process model development

Create custom in-silico Digital Twins of your bioprocesses and cell lines in collaboration with our data science team

Generate mechanistic and hybrid models of your process by leveraging data generated at Culture.

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Benefits

speed
Run virtual experiments

Train models based on your experimental data and use them to predict the performance of experiments.

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Gain insights with data science

Securely collaborate with our team as an extension of your own. Our team of experts is here to help with data selection, model refinement, validation and evaluation.

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Run massive DOEs

Our expert team and custom bioreactors can support large DOEs for data generation purposes including multi-factor screening and other experimental designs.

Capabilities

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Model generation

Use your in-house data in combination with experimental data generated with Culture to build process models (mechanistic, hybrid, predictive run-stopping, etc).

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Data science-driven virtual experiments

Use your process models in a high performance simulator to quickly evaluate thousands of bioreactor conditions based on combining real experimental and simulation data.

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Head-to-head DOE

Compare the tradeoffs of different study types: factor sensitivity, study fragility, etc.

Our facility

Our laboratories based in San Francisco are equipped with segregated modality suites, state-of-the-art bioreactors and analytical instrumentation, all operated by an experienced bioprocess development team.

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350+

250mL and 5L bioreactors

20,000+

Bioreactor runs to date

70+

Customers have used Culture's services to date

High quality & safety standards

Analytical capabilities

Microbial bioprocess
- Biomass quantification
- Metabolite analysis
Mammalian bioprocess
- Viability and cell counts

- Metabolite analysis
- Host cell protein
Protein
- Titer quantification
- Monomer/aggregation quantification
Viral vector
- Capsid titer
- Viral genome titer
- Empty/full ratio

Segregated modality suites

Mammalian
CHO and HEK
Viral vector (AAV)
AAV generated by HEK transfection
Microbial
Yeast, bacteria, and fungi
Media
Media recipes to customer specifications

Rigorous standards

Quality management systems (QMS)
Quality review of all runs and CAPA for major deviations
Safety & security
BSL-2 and SOC2 compliant

Our bioreactors

At Culture, we custom-build our modular reactors with cloud-connected controllers, making bioprocess scale-out, design, monitoring, and analysis as easy as possible.

250mL bench-scale single-use bioreactor

Bioreactor for process development

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5L single-use bioreactor

Bioreactor for process development and material generation

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Culture in your lab

Modular single-use bioreactors designed to be easily scaled up or down

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Optimize your bioprocess with Culture