Services

Process characterization

Use our bioreactors and DOE expertise to characterize your process prior to PPQ

Assess your process in scale-down bioreactors that allow for increased model curvature and variables in your process DOEs.

Scientist with bioreactorsScientists with bioreactors

Benefits

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Debottleneck process characterization

Utilize a large number of bioreactors and dedicated staff to characterize your process. Culture’s DOE expertise can be leveraged to design effective studies to define your Critical Process Parameters (CPPs).

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Avoid large, upfront CAPEX and FTE training

Effectively leverage Culture’s fleet of bioreactors and dedicated expert staff instead of building lab space, hiring specialized staff and commissioning costly capital equipment.

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Transparent and real-time data provided by a proven team

Live data monitoring via our cloud-connected systems enable real-time evaluation of your process characterization runs. This de-risks your experimental investment by enabling faster, in-process decisions and accelerating outcomes.

Capabilities

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Run extensive DOEs

Our team and custom bioreactors can support large DOEs for data generation including multi-factor screening and other experimental designs.

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DOE design and data analysis support

Culture’s team of data scientists can help with DOE design, power analysis and experimental outcome analysis.

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Transparent, real-time data sharing

Our data sharing platform enables real-time access to process trends and analytical data for your process characterization experiments.

Having access to Culture’s Cloud Lab has allowed us to pursue multiple projects simultaneously.
Darcy Prather

Our facility

Our laboratories based in San Francisco are equipped with segregated modality suites, state-of-the-art bioreactors and analytical instrumentation, all operated by an experienced bioprocess development team.

group of scientists with Bioreactors - Culture BioBioreactor - Culture BioBioreactor Lab - Culture Bio

350+

250mL and 5L bioreactors

20,000+

Bioreactor runs to date

70+

Customers have used Culture's services to date

High quality & safety standards

Analytical capabilities

Microbial bioprocess
- Biomass quantification
- Metabolite analysis
Mammalian bioprocess
- Viability and cell counts

- Metabolite analysis
- Host cell protein
Protein
- Titer quantification
- Monomer/aggregation quantification
Viral vector
- Capsid titer
- Viral genome titer
- Empty/full ratio

Segregated modality suites

Mammalian
CHO and HEK
Viral vector (AAV)
AAV generated by HEK transfection
Microbial
Yeast, bacteria, and fungi
Media
Media recipes to customer specifications

Rigorous standards

Quality management systems (QMS)
Quality review of all runs and CAPA for major deviations
Safety & security
BSL-2 and SOC2 compliant

Our bioreactors

At Culture, we custom-build our modular reactors with cloud-connected controllers, making bioprocess scale-out, design, monitoring, and analysis as easy as possible.

250mL bench-scale single-use bioreactor

Bioreactor for process development

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5L single-use bioreactor

Bioreactor for process development and material generation

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Culture in your lab

Modular single-use bioreactors designed to be easily scaled up or down

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Optimize your bioprocess with Culture